Comparison of the new emulsion formulation of propofol with methohexitone and thiopentone for induction of anaesthesia in day cases.

Abstract

The new emulsion formulation of di-isopropyl phenol (propofol) was compared with methohexitone and thiopentone for induction of anaesthesia in day cases. Propofol produced significantly smoother induction of anaesthesia, but caused more cardiovascular and respiratory depression. Pain on injection was significantly less than with methohexitone. Post-anaesthetic recovery was superior with propofol, with virtual absence of side effects, and rapid recovery with little impairment of psychomotor function 30 min after anaesthesia.

• Authors: N Mackenzie, I S Grant
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 57 Issue 8 Pg. 725-31 (Aug 1985) ISSN: 0007-0912 [Print] England
• PMID: 3874640 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anesthetics
• Fat Emulsions, Intravenous
• Phenols
• Methohexital
• Thiopental
• Propofol

Topics

• Adolescent
• Adult
• Aged
• Ambulatory Surgical Procedures
• Anesthesia, Intravenous
• Anesthetics (pharmacology)
• Fat Emulsions, Intravenous
• Female
• Flicker Fusion (drug effects)
• Humans
• Male
• Methohexital (pharmacology)
• Middle Aged
• Phenols (pharmacology)
• Postoperative Period
• Propofol
• Reaction Time (drug effects)
• Thiopental (pharmacology)
• Time Factors