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Hormonal induction of specific protein synthesis in murine Leydig tumor cells.

Abstract
The M5480A murine Leydig cell tumor was used to investigate the effects of three hormones, which produce distinct biochemical actions, on cytoplasmic protein synthesis. Human choriogonadotropin treatment of tumor-bearing mice induced the synthesis of six proteins with relative molecular weights (Mr) of 135K, 82K, 60K, 19K, 18.2K and 17.3K (K = kilodaltons). Diethylstilbestrol induced one protein peak in common with the gonadotropin Mr = 135K) and three additional proteins with Mr's of 120K, 50K and 36K. Epidermal growth factor induced one major protein with Mr = 33K, which is similar to that of a protein induced in murine epidermal cells by tumor promoters. These studies demonstrate the induction of specific gene products in a hormone-responsive tumor.
AuthorsM H Melner, D Puett
JournalBiochemistry international (Biochem Int) Vol. 10 Issue 5 Pg. 763-70 (May 1985) ISSN: 0158-5231 [Print] Australia
PMID3874624 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Chorionic Gonadotropin
  • Epidermal Growth Factor
  • Diethylstilbestrol
Topics
  • Animals
  • Chorionic Gonadotropin (pharmacology)
  • Cytoplasm (metabolism)
  • Diethylstilbestrol (pharmacology)
  • Epidermal Growth Factor (pharmacology)
  • Leydig Cell Tumor (metabolism)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Molecular Weight
  • Protein Biosynthesis
  • Testicular Neoplasms (metabolism)

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