[Circulating metabolites of vitamin D in 14 children with hypercalcemia].

Abstract

Circulating vitamin D metabolite concentrations, i.e. 25-(OH)D, 24,25-(OH)2D, 1,25-(OH)2D have been assayed in 14 hypercalcemic children. Results are as follows: a) Children with vitamin D intoxication (n = 2) had elevated serum 25-(OH)D and 24,25-(OH)2D concentrations but their 1,25-(OH)2D concentrations were similar to those found in normocalcemic children (10-110 pg/ml); b) Children with familial idiopathic hypercalcemia and hypocalciuria (n = 5), children with hypercalcemia and either Bartter's syndrome (n = 1), hemangiomatosis (n = 1), osteopetrosis after medullary graft (n = 1), also had 1,25-(OH)2D concentrations in the normal range; c) In contrast, 1,25-(OH)2D were elevated (160-470 pg/ml) in the four children with severe idiopathic hypercalcemia and elfin facies.

• Authors: E Jacqz, M Garabedian, H Guillozo, A Bourdeau, M Guillot, M F Gagnadoux, M Broyer, G Lenoir, S Balsan
• Journal: Archives francaises de pediatrie (Arch Fr Pediatr) Vol. 42 Issue 3 Pg. 225-30 (Mar 1985) ISSN: 0003-9764 [Print] France
• Vernacular Title: Métabolites circulants de la vitamine D chez 14 enfants en état d'hypercalcémie.
• PMID: 3873927 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Dihydroxycholecalciferols
• Vitamin D
• 24,25-Dihydroxyvitamin D 3
• Calcitriol
• Calcifediol
• Calcium

Topics

• 24,25-Dihydroxyvitamin D 3
• Calcifediol (blood)
• Calcitriol (blood)
• Calcium (urine)
• Child, Preschool
• Dihydroxycholecalciferols (blood)
• Female
• Humans
• Hypercalcemia (blood, etiology, genetics)
• Infant
• Infant, Newborn
• Male
• Vitamin D (metabolism, poisoning)