The failure of cyclosporin to inhibit granulomatous inflammation in acute Arthus-like panophthalmitis.

Abstract

Acute Arthus-like panophthalmitis (AP) was induced in Lewis rat eyes by lens injury after immunization with whole rabbit lens extract. AP consists of an acute anterior ocular inflammation, followed by a posterior choroidal granulomatous reaction. Neither inflammatory response was inhibited by daily treatment with cyclosporin, 10 mg/kg, beginning on the day of lens injury. Cyclosporin would not be expected to interfere with the lens-induced anterior Arthus-like inflammation. The lack of inhibition of the choroidal inflammation was unexpected. The results are interpreted to indicate that the posterior granulomatous choroidal inflammation is a non-immune reaction initiated by the severe lens-induced Arthus-like reaction.

• Authors: A G Palestine, C C Chan, I Gery, R B Nussenblatt
• Journal: Immunology letters (Immunol Lett) Vol. 9 Issue 4 Pg. 235-7 ( 1985) ISSN: 0165-2478 [Print] Netherlands
• PMID: 3873408 (Publication Type: Journal Article)

Chemical References

• Cyclosporins

Topics

• Animals
• Cyclosporins (therapeutic use)
• Female
• Granuloma (immunology, prevention & control)
• Immunity, Cellular (drug effects)
• Inflammation (prevention & control)
• Panophthalmitis (immunology, prevention & control)
• Rats
• Rats, Inbred Lew