A "new" chromosome marker common to the Rett syndrome and infantile autism? The frequency of fragile sites at X p22 in 81 children with infantile autism, childhood psychosis and the Rett syndrome.

Abstract

Chromosomes from 46 autistic, 20 psychotic and 15 Rett syndrome children were cultured in a folic-acid-depleted medium. Nine percent of the autistic, 20% of the psychotic and 40% of the Rett syndrome cases showed a "new" chromosomal anomaly, viz a fragile site at the (X) (p22) location. It is suggested that in some cases of autism/psychosis and the Rett syndrome, there might be a common biological marker for the common type of psychiatric disturbance. However, as the population frequency of the chromosome marker is not yet known, conclusions must be drawn with great caution.

• Authors: C Gillberg, J Wahlström, B Hagberg
• Journal: Brain & development (Brain Dev) Vol. 7 Issue 3 Pg. 365-7 ( 1985) ISSN: 0387-7604 [Print] Netherlands
• PMID: 3864386 (Publication Type: Journal Article)

Chemical References

• Genetic Markers

Topics

• Adolescent
• Autistic Disorder (genetics)
• Female
• Fragile X Syndrome (genetics)
• Genetic Markers
• Humans
• Intellectual Disability (genetics)
• Male
• Neurocognitive Disorders (genetics)
• Sex Chromosome Aberrations (genetics)
• Stereotyped Behavior
• Syndrome