[Clinical experience with cefmenoxime (CMX) in complicated urinary tract infections].

Abstract

Cefmenoxime (CMX) was intravenously administered to 106 patients with complicated urinary tract infection at a daily dose of 2-4 g for 5 days. An excellent response in overall clinical efficacy was seen in 15 cases (18.3%), a moderate response in 46 cases (56.1%) and poor response in 21 cases (25.6%). Pyuria was cleared in 20 cases (24.4%), decreased in 22 cases (26.8%) and unchanged in 40 cases (48.8%). Bacteriuria was eliminated in 41 cases (50.0%), decreased in 17 cases (20.7%), relapsed in 7 cases (8.5%) and unchanged in 17 cases (20.7%). Bacteriologically, 74 (76.8%) of the 95 strains isolated were eradicated by CMX, and 22 (23.2%) persisted. Side effects were observed in 3 (abdominal pain, diarrhea and elevation of trans amylase) of the 106 cases. Judging from the above results, CMX is considered to be a useful drug in the treatment of complicated urinary tract infections.

• Authors: Y Minami, S Kanda, R Matsuo, H Sakai, H Kamemoto, A Hisamatsu, N Maruta, A Johdai, H Shimomae, Y Watanabe
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 31 Issue 6 Pg. 1077-84 (Jun 1985) ISSN: 0018-1994 [Print] Japan
• PMID: 3864365 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cefmenoxime
• Cefotaxime

Topics

• Adolescent
• Adult
• Aged
• Cefmenoxime
• Cefotaxime (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Drug Evaluation
• Female
• Humans
• Infusions, Parenteral
• Injections, Intravenous
• Male
• Middle Aged
• Urinary Tract Infections (drug therapy, microbiology)