Protein C deficiency--response to danazol and DDAVP.

Abstract

We studied a Spanish family in which one of the female members presented recurrent thrombophlebitis in both legs after three different deliveries. Biological and antigenic activity of protein C was decreased (35% and 42% respectively). Reduced protein C levels were also observed in 6 other family members. Administration of danazol (600 mg/day) in two patients with protein C deficiency elevated this protein and discontinuation of the drug resulted in a reduction of protein C to pretreatment values. The proposita showed a normal fibrinolytic activity and infusion of DDAVP produced a similar response of FVIII/VWF and plasminogen activator to those observed in healthy subjects.

• Authors: R Gonzalez, I Alberca, N Sala, V Vicente
• Journal: Thrombosis and haemostasis (Thromb Haemost) Vol. 53 Issue 3 Pg. 320-2 (Jun 24 1985) ISSN: 0340-6245 [Print] Germany
• PMID: 3840287 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glycoproteins
• Pregnadienes
• Protein C
• Antithrombin III
• Prothrombin
• Factor X
• Deamino Arginine Vasopressin
• Danazol

Topics

• Antithrombin III (analysis)
• Danazol
• Deamino Arginine Vasopressin
• Factor X (analysis)
• Female
• Fibrinolysis
• Glycoproteins (analysis, deficiency, genetics)
• Humans
• Male
• Pedigree
• Pregnadienes
• Protein C
• Prothrombin (analysis)
• Reference Values
• Thrombophlebitis (blood, genetics)