Experimental endocarditis and fosfomycin.

Abstract	The effectiveness of fosfomycin in combination with other antibiotics was studied in vitro and in the treatment of left-sided endocarditis in rabbits caused by S. sanguis, S. faecalis, S. aureus or P. aeruginosa. In vitro combinations of fosfomycin plus penicillin, fosfomycin plus cloxacillin, and fosfomycin plus amikacin were synergistic against the strains tested. In vivo synergism was also demonstrated since fosfomycin combinations produced a greater reduction in the number of CFU/g of vegetations than the administration of one antibiotic alone.
Authors	A Rodríguez, M V Vicente, T Olay
Journal	Drugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 11 Issue 1 Pg. 55-62 ( 1985) ISSN: 0378-6501 [Print] Switzerland
PMID	3836112 (Publication Type: Journal Article)
Chemical References	Anti-Bacterial Agents Fosfomycin
Topics	Animals Anti-Bacterial Agents (therapeutic use) Drug Evaluation, Preclinical Drug Synergism Endocarditis, Bacterial (drug therapy) Fosfomycin (therapeutic use) Microbial Sensitivity Tests Pseudomonas Infections (drug therapy) Rabbits Staphylococcal Infections (drug therapy) Stem Cells (drug effects) Streptococcal Infections (drug therapy)

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