Caerulein in the treatment of biliary and renal colic.

Abstract

A randomized controlled study has been carried out in order to check the activity of caerulein in the treatment of biliary and renal colic. In 88% out of 107 patients caerulein, 1 ng/kg IV, relieved biliary colic and had no side effects. To elucidate the mechanism of action of the peptide, 22 cholecystectomized patients, showing a dilation of the common bile duct (CBD), were submitted to caerulein treatment under echo-control. Reduction of CBD caliber was noticed when the dilatation was due to functional obstruction, whereas an organic obstruction of the terminal tract of CBD was found in the non-responding patients. Caerulein appears to be an effective agent in relieving biliary colic through a relaxation of Oddi's sphincter, and may be used in ultrasound differential diagnostics of terminal bile duct obstruction. Caerulein, 75 ng/kg intramuscularly, relieved renal colic in 75% of the examined patients; it is suggested that the effect of caerulein in this syndrome is due to central analgesic action.

• Authors: C Graiff, M Bezza, F Ziller, B Stringari, R Brentari, G Bertagnolli, F Apuzzo, R Mezzena
• Journal: Peptides (Peptides) Vol. 6 Suppl 3 Pg. 47-51 ( 1985) ISSN: 0196-9781 [Print] United States
• PMID: 3831972 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Ceruletide

Topics

• Adolescent
• Aged
• Biliary Tract Diseases (drug therapy)
• Ceruletide (therapeutic use)
• Colic (drug therapy)
• Double-Blind Method
• Female
• Humans
• Kidney Diseases (drug therapy)
• Male
• Middle Aged