Failure of metoclopramide to control emesis or nausea due to stressful angular or linear acceleration.

Abstract

Orally administered metoclopramide (REGLAN) at doses of 10 or 20 mg, 75 min prior to either stressful linear acceleration (parabolic flight) or cross-coupled accelerative semicircular canal stimulation in a rotating chair was evaluated for its ability to prevent emesis or nausea II, respectively. Although metoclopramide is an effective antiemetic agent that enhances gastric emptying and prevents cancer chemotherapy-induced emesis, we were unable to demonstrate any significant (p less than 0.05) effects of this drug on motion sickness.

• Authors: R L Kohl
• Journal: Aviation, space, and environmental medicine (Aviat Space Environ Med) Vol. 58 Issue 2 Pg. 125-31 (Feb 1987) ISSN: 0095-6562 [Print] United States
• PMID: 3827787 (Publication Type: Journal Article)

Chemical References

• Metoclopramide

Topics

• Acceleration (adverse effects)
• Adult
• Coriolis Force
• Humans
• Metoclopramide (therapeutic use)
• Motion Sickness (drug therapy, etiology)
• Nausea (drug therapy, etiology)
• Space Flight