Three days cefoxitin in perforated appendicitis.

Abstract

This study was undertaken to assess the efficacy and safety of a 3-day course of treatment with Mefoxitin (cefoxitin sodium, MSD) in patients with perforated or ruptured appendicitis. A series of 235 patients undergoing surgery for perforated or ruptured appendicitis were treated with cefoxitin for 3 days. Twenty-four patients (10%) developed wound infection and 28 (12%) developed an intra-abdominal abscess postoperatively. No side effects were observed during the study. Compared with the results of our previous series, where a 5-day course of cefoxitin was used, the incidence of wound infection was similar. However the incidence of intra-abdominal abscesses in the present series was significantly higher (p less than 0.01). The results seem to indicate that a 3-day course of cefoxitin is as effective as a 5-day course in controlling the incidence of wound infection following surgery for perforated or ruptured appendicitis, whereas the 3-day course seems to be inferior to a 5-day course in controlling the incidence of intra-abdominal abscesses.

• Authors: G Lose, B Holm, T Bauer, P Graversen, E S Kristensen, E Larsen, M Persson, H Skjoldborg, B Vennits
• Journal: Annales chirurgiae et gynaecologiae (Ann Chir Gynaecol) Vol. 75 Issue 5 Pg. 270-3 ( 1986) ISSN: 0355-9521 [Print] Finland
• PMID: 3827166 (Publication Type: Journal Article)

Chemical References

• Cefoxitin

Topics

• Abscess (epidemiology)
• Adolescent
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Appendicitis (surgery)
• Cefoxitin (therapeutic use)
• Child
• Child, Preschool
• Female
• Humans
• Intestinal Perforation (surgery)
• Male
• Middle Aged
• Rupture, Spontaneous
• Surgical Wound Infection (epidemiology, prevention & control)