Cardiovascular effects of ZSY-27 [5-methyl-6-(4-pyridinyl)-2H-1,4-thiazine-3(4H)-one X hydrochloride] in the dog cross-circulated atrial preparation.

A new cardiotonic compound, 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazine-3(4H)-one X hydrochloride (ZSY-27), was investigated in cross-circulated dog atrial muscle preparations. When ZSY-27 was intravenously administered to the donor dog, a dose-dependent depressor effect with slight sinus tachycardia was induced in the donor dog. At the same time, a significant dose-dependent increase in developed tension was usually observed in an isolated atrium perfused with donor's arterial blood, but there were no significant changes in sinus cycle length and sinoatrial conduction time. The ZSY-27-induced positive inotropic effect was not significantly influenced by treatment with propranolol in doses which completely inhibited norepinephrine-induced positive chronotropic and inotropic effects. When ZSY-27 was injected into the cannulated sinus node artery of the isolated atrium, dose dependent positive chronotropic and inotropic effects were induced. The dominant increases in developed tension by ZSY-27 were similar to effects of other phosphodiesterase inhibitors, such as papaverine and aminophylline. From these results, it is concluded that ZSY-27 has non-adrenergic, cardiotonic properties with a depressor effect.
AuthorsS Chiba, Y Furukawa, K Saegusa, Y Ogiwara
JournalJapanese heart journal (Jpn Heart J) Vol. 27 Issue 5 Pg. 749-57 (Sep 1986) ISSN: 0021-4868 [Print] JAPAN
PMID3820580 (Publication Type: Journal Article)
Chemical References
  • Phosphodiesterase Inhibitors
  • Thiazines
  • Aminophylline
  • ZSY 27
  • Papaverine
  • Aminophylline (pharmacology)
  • Animals
  • Cardiac Pacing, Artificial
  • Cross Circulation
  • Dogs
  • Dose-Response Relationship, Drug
  • Female
  • Heart (drug effects)
  • Heart Atria (drug effects)
  • Heart Conduction System (drug effects)
  • Injections, Intra-Arterial
  • Male
  • Models, Biological
  • Myocardial Contraction (drug effects)
  • Papaverine (pharmacology)
  • Phosphodiesterase Inhibitors (administration & dosage, pharmacology)
  • Stimulation, Chemical
  • Thiazines (administration & dosage, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: