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Flunisolide nasal spray for perennial rhinitis in children.

Abstract
Twenty-seven children with perennial rhinitis entered a double-blind cross-over study comparing nasal sprays of flunisolide---a new topical corticosteroid---and placebo. Symptoms were assessed over two consecutive monthly periods with each treatment. Weekly diary cards, monthly clinical assessments, and end-of-trial preferences all favoured the active drug. At the end of the trial 20 patients preferred the treatment month with flunisolide, four preferred the placebo month, and two rated the periods equally. Side effects were mild, the commonest being transient nasal stinging. Seventeen children who derived benefit from flunisolide continued with the treatment for a six-month open-study period. Many reduced the dosage from three times to twice or once daily without losing benefit. The effect of flunisolide on the pituitary-adrenal axis was assessed in seven children by measuring the 0900 blood cortisol concentrations at two-month intervals over the six months. No effect was observed. The results show that flunisolide is effective and safe for the treatment and prophylaxis of perennial rhinitis in children.
AuthorsJ K Sarsfield, G E Thomson
JournalBritish medical journal (Br Med J) Vol. 2 Issue 6182 Pg. 95-7 (Jul 14 1979) ISSN: 0007-1447 [Print] England
PMID380773 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Aerosols
  • Fluocinolone Acetonide
  • flunisolide
Topics
  • Adolescent
  • Aerosols
  • Child
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Fluocinolone Acetonide (administration & dosage, analogs & derivatives, therapeutic use)
  • Humans
  • Male
  • Random Allocation
  • Respiratory Therapy
  • Rhinitis, Allergic, Seasonal (drug therapy)

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