Effect of a Salmonella group H1 R factor on virulence and response of infections to antimicrobial therapy.

Abstract

A group H1 R factor encoding resistance to chloramphenicol, streptomycin, sulfonamide, and tetracycline was transferred into Salmonella typhimurium LT-2. The virulence of LT-2 for mice, as assessed by intraperitoneal 50% lethal dose and the number of organisms in the spleen, was not affected by the R factor. On the other hand, the R factor conferred resistance in mouse infections to therapy with chloramphenicol and trimethoprim plus sulfamethoxazole.

• Authors: T Butler, C W Shuster, A Franco
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 15 Issue 3 Pg. 478-80 (Mar 1979) ISSN: 0066-4804 [Print] United States
• PMID: 380460 (Publication Type: Journal Article)

Topics

• Animals
• Mice
• R Factors
• Salmonella Infections (drug therapy, microbiology)
• Salmonella typhimurium (genetics, pathogenicity)
• Time Factors