Cefamandole therapy in anaerobic infections.

Abstract

Thirty-one adult patients with infections due to anaerobic bacteria were treated with cefamandole. Bacteroides fragilis group (17) and Bacteroides melaninogenicus (13) were the most frequent anaerobes isolated. Duration of therapy varied from 2 to 49 days. Results were judged satisfactory in 26 cases, and unsatisfactory in 1 case. Four cases could not be evaluated. Adverse reactions occurred in 16 patients and included positive direct Coombs' test without hemolysis, transient liver function abnormalities, phlebitis, reversible neutropenia, fever, eosinophilia, and toxic epidermal necrolysis. The more significant reactions were associated with prolonged therapy. None was lethal. These data suggest that cefamandole is effective in treatment of most anaerobic infections.

• Authors: R N Greenberg, M C Scalcini, C V Sanders, A C Lewis
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 15 Issue 3 Pg. 337-41 (Mar 1979) ISSN: 0066-4804 [Print] United States
• PMID: 380458 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Cephalosporins
• Cefamandole

Topics

• Adult
• Anaerobiosis
• Bacterial Infections (drug therapy, microbiology)
• Cefamandole (adverse effects, metabolism, therapeutic use)
• Cephalosporins (therapeutic use)
• Clinical Trials as Topic
• Humans
• Microbial Sensitivity Tests
• Time Factors