[Clinical effectiveness of carbenicillin in suppurative inflammatory processes of varying localization].

Abstract

The study on sensitivity of clinical strains of the causative agents of purulent infections to carbenicillin showed that 34.6% of the staphylococcal strains, 48.1% of the E. coli strains and 40.3% of the Proteus strains were sensitive to the antibiotic. The strains of Ps. aeruginosa were characterized by moderate sensitivity to carbenicillin. The MTC for most of the isolates ranged within 25-128 microgram/ml. High therapeutic efficacy of carbenicillin in treatment of cases with purulent inflammatory processes of various localization was shown. Positive results were obtained in 82.5% of the adults and 76.2% of the premature infants treated with carbenicillin. A satisfactory therapeutic effect was observed in the cases with sepsis, diffuse purulent peritonitis and abscessing pneumonia treated with carbenicillin in combination with gentamicin.

• Authors: V P Pozdniakova, M A Petrova, A M Marshak, R V Makarenkova, I P Zamotaev
• Journal: Antibiotiki (Antibiotiki) Vol. 24 Issue 7 Pg. 526-31 (Jul 1979) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Klinicheskaia éffektivnost' karbenitsillina pri gnoĭno-vospalitel'-nykh protsessakh razlichnoĭ lokalizatsii.
• PMID: 380455 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Gentamicins
• Ampicillin
• Carbenicillin

Topics

• Adult
• Ampicillin (therapeutic use)
• Carbenicillin (therapeutic use)
• Clinical Trials as Topic
• Drug Evaluation
• Drug Therapy, Combination
• Gentamicins (therapeutic use)
• Humans
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (drug therapy)
• Inflammation (drug therapy)
• Microbial Sensitivity Tests
• Suppuration (drug therapy)