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Delta-infection and suppression of hepatitis B virus replication in chronic HBsAg carriers.

Abstract
The presence of hepatitis B virus DNA and anti-delta was examined in a longitudinal study of 24 patients known to be delta-infected during the course from acute to chronic hepatitis B virus infection. Fifteen patients (63%) were hepatitis B virus DNA positive in the first serum sample. Eleven of 14 patients, who cleared hepatitis B virus DNA, did so following or at the same time as onset of delta-infection. Duration of hepatitis B virus DNA positivity in these 11 patients was shorter than in 11 anti-delta-negative controls matched according to duration of preceding hepatitis B virus DNA positivity, but the difference was not statistically significant. Considering only patients positive for IgM anti-delta in the last serum sample (eight patients), a statistically significant shorter duration of hepatitis B virus DNA positivity was found in delta-infected patients than in the controls (p less than 0.02). The study indicates that the delta-agent may have the capacity to inhibit hepatitis B virus replication and that a chronic delta-infection may lead to a termination of the period of active viral replication.
AuthorsK Krogsgaard, P Kryger, J Aldershvile, P Andersson, T I Sørensen, J O Nielsen
JournalHepatology (Baltimore, Md.) (Hepatology) 1987 Jan-Feb Vol. 7 Issue 1 Pg. 42-5 ISSN: 0270-9139 [Print] United States
PMID3804204 (Publication Type: Journal Article)
Chemical References
  • Antigens, Viral
  • DNA, Viral
  • Hepatitis B Surface Antigens
Topics
  • Adolescent
  • Adult
  • Antigens, Viral (immunology)
  • Carrier State (immunology)
  • Chronic Disease
  • DNA, Viral (analysis)
  • Female
  • Hepatitis B Surface Antigens (immunology)
  • Hepatitis B virus (physiology)
  • Hepatitis D (microbiology)
  • Hepatitis Delta Virus (immunology)
  • Humans
  • Male
  • Middle Aged
  • Virus Replication

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