Abstract |
The presence of hepatitis B virus DNA and anti-delta was examined in a longitudinal study of 24 patients known to be delta-infected during the course from acute to chronic hepatitis B virus infection. Fifteen patients (63%) were hepatitis B virus DNA positive in the first serum sample. Eleven of 14 patients, who cleared hepatitis B virus DNA, did so following or at the same time as onset of delta-infection. Duration of hepatitis B virus DNA positivity in these 11 patients was shorter than in 11 anti-delta-negative controls matched according to duration of preceding hepatitis B virus DNA positivity, but the difference was not statistically significant. Considering only patients positive for IgM anti-delta in the last serum sample (eight patients), a statistically significant shorter duration of hepatitis B virus DNA positivity was found in delta-infected patients than in the controls (p less than 0.02). The study indicates that the delta-agent may have the capacity to inhibit hepatitis B virus replication and that a chronic delta-infection may lead to a termination of the period of active viral replication.
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Authors | K Krogsgaard, P Kryger, J Aldershvile, P Andersson, T I Sørensen, J O Nielsen |
Journal | Hepatology (Baltimore, Md.)
(Hepatology)
1987 Jan-Feb
Vol. 7
Issue 1
Pg. 42-5
ISSN: 0270-9139 [Print] United States |
PMID | 3804204
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Viral
- DNA, Viral
- Hepatitis B Surface Antigens
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Topics |
- Adolescent
- Adult
- Antigens, Viral
(immunology)
- Carrier State
(immunology)
- Chronic Disease
- DNA, Viral
(analysis)
- Female
- Hepatitis B Surface Antigens
(immunology)
- Hepatitis B virus
(physiology)
- Hepatitis D
(microbiology)
- Hepatitis Delta Virus
(immunology)
- Humans
- Male
- Middle Aged
- Virus Replication
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