[Effect of an opioid peptide on the healing of experimental myocardial infarct].

Abstract

The effect of an opioid hormone (Leu-enkephalin analog Tyr-Dala-Gly-Phe-Leu-Arg) on the healing of myocardial infarction caused by the ligation of the descending branch of the rabbit left coronary artery has been investigated. The peptide was injected intraperitoneally at a dose of 10 micrograms/kg daily. Using light and electron microscopy, the peptide has been shown to exert a pronounced stimulating effect on the healing of the necrotic zone on days 3 and 7 of the experiment. Opioid peptides are suggested to take part in the healing of various disorders.

• Authors: N I Afonskaia, O B Il'inskiĭ, V F Kondalenko, S E Spevak, N M Cherpachenko
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 102 Issue 12 Pg. 754-7 (Dec 1986) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie opioidnogo peptida na zazhivlenie éksperimental'nogo infarkta miokarda.
• PMID: 3801632 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Enkephalin, Leucine
• Enkephalin, Leucine-2-Alanine
• enkephalin-Leu, Ala(2)-Arg(6)-

Topics

• Animals
• Drug Evaluation, Preclinical
• Enkephalin, Leucine (analogs & derivatives, therapeutic use)
• Enkephalin, Leucine-2-Alanine (analogs & derivatives)
• Male
• Microscopy, Electron
• Myocardial Infarction (drug therapy, pathology)
• Myocardium (ultrastructure)
• Necrosis
• Rabbits
• Time Factors
• Wound Healing (drug effects)