Effect of low-dose aspirin on angiotensin II pressor response in human pregnancy.

Abstract

Recent clinical studies have reported a significant reduction in the incidence of pregnancy-induced hypertension after the ingestion of low-dose aspirin. The effect of 80 mg of acetylsalicylic acid on vascular sensitivity to exogenous angiotensin II (Hypertensin, Ciba-Geigy Limited, Basel, Switzerland) was examined in 13 normotensive pregnant patients. The effective pressor dose before treatment (17.4 +/- 2.2 ng/kg/min) (mean +/- SE) was significantly less (p less than 0.001) than that after treatment (35.1 +/- 4.2 ng/kg/min). Low-dose aspirin therapy resulted in an enhancement of the pregnancy-acquired refractoriness to angiotensin II. It can be speculated that prostaglandin synthetase inhibitors at a low dose may alter the thromboxane A2/prostacyclin ratio in favor of the latter.

• Authors: L Sanchez-Ramos, M J O'Sullivan, J Garrido-Calderon
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 156 Issue 1 Pg. 193-4 (Jan 1987) ISSN: 0002-9378 [Print] United States
• PMID: 3799752 (Publication Type: Journal Article)

Chemical References

• Angiotensin II
• Aspirin

Topics

• Angiotensin II (pharmacology)
• Aspirin (administration & dosage, pharmacology)
• Blood Pressure (drug effects)
• Female
• Humans
• Pregnancy (physiology)
• Time Factors