HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[A study of malignancy in gastro-intestinal carcinoids with special reference to the association of the prognosis and peptide hormone or oncofetal protein producing pattern].

Abstract
It is difficult to differentiate malignant carcinoid tumors from benign ones early in the course of the illness. We investigated retrospectively a series of thirty-nine gastro-intestinal carcinoids not only for primary tumor anatomic site, macroscopic type, tumor size, histological depth, vessel invasion and mitosis, but also for peptide, ectopic hormone and oncofetal proteins by immunohistochemistry. Carcinoids primary in the appendix or rectum rarely metastasize, but those primary in the stomach or colon grow rapidly. Those greater than 2 cm in diameter and Borrmann's type had a poor prognosis. Carcinoids with deep penetration, vessel invasion or mitosis easily metastasize to lymph nodes or to the liver. Peptide hormone producing carcinoids were present in 21 of 39 (54%) tumors, but there were no correlation between the prognosis and peptide hormone producing patterns. Carcinoids producing carcinoembryonic antigen (CEA) were demonstrated in 11 of 37 (29%) tumors. These tumors were greater in size, more deeply penetrating and had more remarkable vessel invasion and mitosis than CEA non-producing ones. These results show that CEA producing carcinoids grow rapidly and easily metastasize. We concluded that these findings in carcinoid tissue appeared to be a reliable markers for metastasis and poor prognosis.
AuthorsY Yonemura, T Hashimoto, Y Shima, G Nishimura, A Yamaguchi, I Miyazaki, S Takashima
JournalNihon Geka Gakkai zasshi (Nihon Geka Gakkai Zasshi) Vol. 87 Issue 10 Pg. 1324-9 (Oct 1986) ISSN: 0301-4894 [Print] Japan
PMID3796578 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Carcinoembryonic Antigen
  • Hormones, Ectopic
Topics
  • Carcinoembryonic Antigen (biosynthesis)
  • Carcinoid Tumor (metabolism, pathology)
  • Gastrointestinal Neoplasms (metabolism, pathology)
  • Hormones, Ectopic (biosynthesis)
  • Humans
  • Neoplasm Staging
  • Prognosis
  • Prospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: