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Pharmacokinetic study of ioxaglate, a low osmolality contrast medium, in patients with renal failure.

Abstract
Determination of changes in plasma concentration of ioxaglate in patients with renal failure made it possible to demonstrate that distribution and clearance of this contrast medium, as in the case of classic uroangiographic products, conform to an open two-compartment model with clearance from the central compartment. Various pharmacokinetic parameters were calculated. The metabolic clearance of ioxaglate was lower for all 6 patients studied, as compared with results for 3 normal subjects tested, but less marked than with iodamide, a contrast medium involving tubular secretion.
AuthorsM Bourin, V Laporte, J Guenzet, S Langlois, J Pengloan, P Rouleau
JournalInternational journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 24 Issue 11 Pg. 614-21 (Nov 1986) ISSN: 0174-4879 [Print] Germany
PMID3793295 (Publication Type: Journal Article)
Chemical References
  • Ioxaglic Acid
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Humans
  • Ioxaglic Acid (blood)
  • Kidney Failure, Chronic (blood)
  • Kinetics
  • Mathematics
  • Metabolic Clearance Rate
  • Middle Aged
  • Models, Biological
  • Osmolar Concentration

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