[Splenectomy in paroxysmal nocturnal hemoglobinuria with pancytopenia].

Abstract

Two patients with long known paroxysmal nocturnal haemoglobinuria (PNH) were hospitalized for progressive severe pancytopenia or thrombocytopenia. Clinical and laboratory findings revealed a hematologic complication related to the course of PNH. In view of normocellular bone marrow hematopoiesis and documented increased splenic sequestration of RBC, functional hypersplenism was diagnosed. Selective splenectomy confirmed this hypothesis and was followed by long-standing remission of pancytopenia for 10 or more years in both patients.

• Authors: B Frey, R Flury, H J Senn
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 116 Issue 42 Pg. 1450-2 (Oct 18 1986) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Splenektomie bei paroxysmaler nächtlicher Hämoglobinurie mit Panzytopenie.
• PMID: 3787227 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Aged
• Female
• Hematopoiesis
• Hemoglobinuria, Paroxysmal (complications, physiopathology, therapy)
• Humans
• Hypersplenism (physiopathology)
• Male
• Middle Aged
• Pancytopenia (etiology, physiopathology, therapy)
• Splenectomy