Abstract |
Thirty children with simple febrile convulsions were treated with sodium valproate following their second convulsion. Twenty-two of the 30 (73%) had no further convulsions during the one-year period of observation compared with 17 of 28 in the control group (61%). This was not a statistically significant difference. Side effects attributed to sodium valproate treatment were noted in 7 patients (23%), although 4 of these showed only mild transient gastrointestinal symptoms at high dosage. The study did not confirm any advantage in the use of sodium valproate as a prophylaxis for febrile convulsions, although compliance was good and significant side effects infrequent.
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Authors | A J Williams, L G Evans-Jones, A D Kindley, P J Groom |
Journal | Clinical pediatrics
(Clin Pediatr (Phila))
Vol. 18
Issue 7
Pg. 426-30
(Jul 1979)
ISSN: 0009-9228 [Print] United States |
PMID | 378504
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Chemical and Drug Induced Liver Injury
(etiology)
- Child
- Child, Preschool
- Drug Evaluation
- Fever
(complications)
- Gastrointestinal Diseases
(chemically induced)
- Humans
- Infant
- Patient Compliance
- Seizures
(etiology, prevention & control)
- Valproic Acid
(adverse effects, therapeutic use)
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