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Sodium valproate in the prophylaxis of simple febrile convulsions.

Abstract
Thirty children with simple febrile convulsions were treated with sodium valproate following their second convulsion. Twenty-two of the 30 (73%) had no further convulsions during the one-year period of observation compared with 17 of 28 in the control group (61%). This was not a statistically significant difference. Side effects attributed to sodium valproate treatment were noted in 7 patients (23%), although 4 of these showed only mild transient gastrointestinal symptoms at high dosage. The study did not confirm any advantage in the use of sodium valproate as a prophylaxis for febrile convulsions, although compliance was good and significant side effects infrequent.
AuthorsA J Williams, L G Evans-Jones, A D Kindley, P J Groom
JournalClinical pediatrics (Clin Pediatr (Phila)) Vol. 18 Issue 7 Pg. 426-30 (Jul 1979) ISSN: 0009-9228 [Print] United States
PMID378504 (Publication Type: Journal Article)
Chemical References
  • Valproic Acid
Topics
  • Chemical and Drug Induced Liver Injury (etiology)
  • Child
  • Child, Preschool
  • Drug Evaluation
  • Fever (complications)
  • Gastrointestinal Diseases (chemically induced)
  • Humans
  • Infant
  • Patient Compliance
  • Seizures (etiology, prevention & control)
  • Valproic Acid (adverse effects, therapeutic use)

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