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Long-term follow-up of 60 patients with chronic hepatitis B. II. Hepatitis B virus DNA in serum correlated to the hepatitis Be-system and presence of delta superinfection.

Abstract
Forty-six patients with liver biopsy-documented chronic hepatitis B were followed for a mean period of 44 months. A total of 200 serum samples from these patients was analyzed for the presence of hepatitis B virus DNA (HBV-DNA). The results were correlated to the HBeAg/anti-HBe status and to the presence of anti-delta as a marker for delta superinfection. In the initial serum samples HBV-DNA was detected in the vast majority of the patients independent of the HBeAg/anti-HBe results and whether the patients were superinfected by delta agent or not. During the complete follow-up period, HBV-DNA was detected in 88% of those patients who were positive for HBeAg, irrespective of the presence or absence of a simultaneous delta infection. When anti-HBe positive, 79% of the patients with anti-delta had detectable HBV-DNA in their sera, while only 43% of those negative for anti-delta were positive for HBV-DNA. The results indicate a high prevalence of virus release into the blood of patients with chronic hepatitis B, especially among patients positive for HBeAg and among those anti-HBe positive patients who have a delta superinfection.
AuthorsB G Hansson, G Lindh, O Weiland, H Glaumann, M von Sydow, E Nordenfeldt
JournalLiver (Liver) Vol. 6 Issue 5 Pg. 292-6 (Oct 1986) ISSN: 0106-9543 [Print] Denmark
PMID3784784 (Publication Type: Journal Article)
Chemical References
  • DNA, Viral
  • Hepatitis Antibodies
  • Hepatitis B e Antigens
Topics
  • Acquired Immunodeficiency Syndrome (complications)
  • Chronic Disease
  • DNA, Viral (blood)
  • Female
  • Follow-Up Studies
  • Hepatitis Antibodies (analysis)
  • Hepatitis B (complications, microbiology)
  • Hepatitis B e Antigens (analysis, immunology)
  • Hepatitis B virus (genetics)
  • Hepatitis D (complications, microbiology)
  • Humans
  • Male

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