Study of the elimination kinetics of torasemide, a novel loop diuretic, in renal insufficiency.

Abstract

The plasma concentration of torasemide was determined as a function of time in 8 patients with impaired renal function (creatinine clearance less than or equal to 25 ml/min). The elimination half-life (1.3 to 3.8 h), the volume of distribution (0.12 to 0.29 l/kg), and the total body clearance (0.02 to 0.10 l/kg X h) were similar to those observed in normal volunteers.

• Authors: L Dodion, J L Willems
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 31 Suppl Pg. 49-51 ( 1986) ISSN: 0031-6970 [Print] Germany
• PMID: 3780839 (Publication Type: Journal Article)

Chemical References

• Diuretics
• Sulfonamides
• Torsemide

Topics

• Adult
• Aged
• Diuretics (metabolism)
• Female
• Half-Life
• Humans
• Kidney Diseases (metabolism)
• Kinetics
• Male
• Middle Aged
• Sulfonamides (metabolism)
• Torsemide