Serological analysis of H-2 antigens expression on the cell surface of drug- and lectin-resistant mouse tumor cells.

Abstract

The results of studies on the H-2 antigens expression on L1210 and P388 mouse lymphoma cells and their drug-resistant sublines as well as on Lewis lung carcinoma (LL2) cells and their wheat germ agglutinin-resistant variants (LL(2)5 and LL(2)8) are presented. The results revealed no qualitative alterations in H-2 antigens expression on cells of L1210 and P388 leukemias and their drug-resistant sublines. However, as determined by cytotoxic assay the increase relative to parental lines in the expression of normal H-2d antigens on cells of both drug-resistant sublines was observed. Using quantitative absorption assay in addition to differentiate quantitative expression of normal H-2b antigens, the presence of alien H-2k and H-2d specificities on lectin-resistant cells of Lewis lung carcinoma was detected.

• Authors: A Opolski, D Duś, C Radzikowski
• Journal: Archivum immunologiae et therapiae experimentalis (Arch Immunol Ther Exp (Warsz)) Vol. 34 Issue 1 Pg. 21-34 ( 1986) ISSN: 0004-069X [Print] Switzerland
• PMID: 3778114 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Neoplasm
• Antigens, Surface
• H-2 Antigens
• Lectins
• Wheat Germ Agglutinins

Topics

• Animals
• Antigens, Neoplasm (analysis)
• Antigens, Surface (analysis)
• Cell Line
• Cytotoxicity Tests, Immunologic
• Drug Resistance
• H-2 Antigens (analysis)
• Haplotypes
• Lectins (pharmacology)
• Leukemia L1210 (immunology, pathology)
• Leukemia P388 (immunology, pathology)
• Leukemia, Experimental (immunology)
• Lung Neoplasms (immunology)
• Lymphoma (immunology)
• Mice
• Mice, Inbred Strains
• Neoplasms, Experimental (immunology, pathology)
• Wheat Germ Agglutinins (pharmacology)