Single-dose antibiotic prophylaxis in high-risk patients undergoing cesarean section. A comparative trial.

Abstract

A prospective, double-blind study was performed to evaluate the comparative efficacy of single- and multiple-dose antimicrobial prophylaxis for preventing infection in high-risk patients undergoing cesarean section. One hundred fifty-eight patients were randomly assigned to receive either a single perioperative dose of mezlocillin, three doses of mezlocillin or three doses of cefoxitin. The incidence of endometritis was 5.9%, 4.0% and 4.0%, respectively. The incidence of febrile morbidity was 5.9%, 2.0% and 6.1%, respectively. These differences are not statistically significant. The single perioperative dose of mezlocillin was as effective as the three-dose regimen of either mezlocillin or cefoxitin.

• Authors: D H Saltzman, L J Eron, R E Tuomala, L J Protomastro, J G Sites
• Journal: The Journal of reproductive medicine (J Reprod Med) Vol. 31 Issue 8 Pg. 709-12 (Aug 1986) ISSN: 0024-7758 [Print] United States
• PMID: 3772891 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Cefoxitin
• Mezlocillin

Topics

• Adult
• Bacterial Infections (prevention & control)
• Cefoxitin (administration & dosage, therapeutic use)
• Cesarean Section
• Double-Blind Method
• Endometritis (etiology, microbiology)
• Female
• Humans
• Mezlocillin (administration & dosage, therapeutic use)
• Postoperative Complications
• Pregnancy
• Premedication
• Prospective Studies
• Random Allocation
• Urinary Tract Infections (etiology, microbiology)