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Acute hypokalemic effect of gossypol.

Abstract
Clinical trials had demonstrated that chronic ingestion of gossypol induced infertility in males. Hypokalemia of various severities were reported in volunteers taking gossypol. The purpose of this study is to investigate the effects of acute gossypol infusion into alkalotic rats. Plasma potassium concentration decreased from 4.08 to 2.87 mM after gossypol infusion with minimal change in urinary potassium excretion. The hypokalemic effect of gossypol was also observed in nephretomized rats. Some of the factors that are known to affect potassium distribution between the extracellular and intracellular fluid compartment have been investigated in these rats. Plasma glucose concentration was not significantly altered. Gossypol induced hypokalemia was not blocked in rats treated with propranolol. It is therefore believed that the acute hypokalemic effect of gossypol is a direct shifting of potassium into cells.
AuthorsS C Tam
JournalCanadian journal of physiology and pharmacology (Can J Physiol Pharmacol) Vol. 64 Issue 7 Pg. 881-4 (Jul 1986) ISSN: 0008-4212 [Print] Canada
PMID3768796 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Gossypol
  • Potassium
Topics
  • Acid-Base Equilibrium (drug effects)
  • Animals
  • Blood Glucose (analysis)
  • Cell Membrane Permeability (drug effects)
  • Extracellular Space (drug effects)
  • Gossypol (pharmacology)
  • Kidney (metabolism)
  • Male
  • Nephrectomy
  • Potassium (blood, urine)
  • Rats
  • Water-Electrolyte Balance (drug effects)

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