Abstract |
The clinical efficacies of two different single-dose, oral treatments with ciprofloxacin were evaluated in a double-blind randomized study of 50 men with gonococcal urethritis. Two groups of patients were studied. The 25 patients in group A (age, 18-32 years; mean = 26.2) received a single dose of 250 mg of ciprofloxacin; the 25 in group B (age, 16-42 years; mean = 26.3) received a single dose of 100 mg of ciprofloxacin. The minimal inhibitory concentrations of ciprofloxacin for all the isolates were less than or equal to 0.0015 microgram/ml. Neisseria gonorrhoeae was eradicated from all 50 patients; 80% of them were clinically cured, and 20% developed postgonococcal urethritis. There was no significant difference between the two treatments evaluated. We conclude that a single oral dose of 100 mg of ciprofloxacin could be an alternative treatment for uncomplicated gonorrhea in men. Neither treatment prevented the development of postgonococcal urethritis.
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Authors | J Aznar, R Prados, A Rodriguez-Pichardo, I Hernandez, C De Miguel, E J Perea |
Journal | Sexually transmitted diseases
(Sex Transm Dis)
1986 Jul-Sep
Vol. 13
Issue 3
Pg. 169-71
ISSN: 0148-5717 [Print] United States |
PMID | 3764628
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Ciprofloxacin
(administration & dosage, therapeutic use)
- Double-Blind Method
- Gonorrhea
(drug therapy)
- Humans
- Male
- Random Allocation
- Urethritis
(drug therapy)
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