Abstract |
N-Acetyl-beta-D-glucosaminidase (NAG) activity and beta 2-microglobulin (beta 2-m) concentration were measured in the urine of inhabitants of a cadmium-polluted area (Cd), including patients with, or suspected, " itai-itai" disease and control subjects. Urinary NAG activity increased with increasing beta 2-m concentration up to about 100 U/g creatinine; above this value the NAG activity did not increase with increasing beta 2-m concentration. Urinary NAG activity thus represents another useful indicator of renal tubular damage caused by Cd poisoning since the mechanisms for the excretion of NAG and beta 2-m into urine are thought to be different.
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Authors | K Nogawa, Y Yamada, T Kido, R Honda, M Ishizaki, I Tsuritani, E Kobayashi |
Journal | The Science of the total environment
(Sci Total Environ)
Vol. 53
Issue 3
Pg. 173-8
(Sep 1986)
ISSN: 0048-9697 [Print] Netherlands |
PMID | 3764409
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Hexosaminidases
- Acetylglucosaminidase
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Topics |
- Acetylglucosaminidase
(urine)
- Cadmium Poisoning
(diagnosis, enzymology)
- Clinical Enzyme Tests
- Hexosaminidases
(urine)
- Humans
- Reference Values
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