[Evaluation of H2 receptor blockade with metiamide in stress ulcers in rats].

Abstract

Restrain stress in rats inhibits gastric secretion and microcirculation. Secretion is further inhibited by metiamide, but mucosal blood flow is restored to normal. During stress the ulcer incidence is high, lower with prophylactic administration of metiamide and least with the latter and preserved gastroduodenal acid transit. No therapeutic metiamide effect can be detected.

• Authors: G Lang, P O Schwille, R Thun, W Schellerer
• Journal: Chirurgisches Forum fur experimentelle und klinische Forschung (Chir Forum Exp Klin Forsch) Pg. 212-6 (Apr 1977) ISSN: 0303-6227 [Print] Germany
• Vernacular Title: Bewertung der H2-Receptorenblockade mit Metiamid beim Stressulcus der Ratte.
• PMID: 376239 (Publication Type: Journal Article)

Chemical References

• Receptors, Histamine
• Receptors, Histamine H2
• Aminopyrine
• Metiamide
• Pepsin A
• Thiourea

Topics

• Aminopyrine (metabolism)
• Animals
• Gastric Juice (metabolism)
• Gastric Mucosa (blood supply, metabolism)
• Male
• Metiamide (pharmacology, therapeutic use)
• Microcirculation
• Pepsin A (metabolism)
• Rats
• Receptors, Histamine (drug effects)
• Receptors, Histamine H2 (drug effects)
• Restraint, Physical
• Stomach Ulcer (drug therapy, etiology, prevention & control)
• Stress, Physiological (complications)
• Thiourea (analogs & derivatives)