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The antimicrobial activity of ciprofloxacin against Legionella species and the treatment of experimental Legionella pneumonia in guinea pigs.

Abstract
The antimicrobial activity of ciprofloxacin was tested against 15 standard reference strains, and 37 clinical and environmental strains of Legionella pneumophila by an agar dilution method, using a new growth medium (B-SYE agar) which we devised. The minimal inhibitory concentrations of ciprofloxacin were found to be inoculum dependent, and ranged from 0.02 to 0.06 mg/l at 10(4) cfu inoculum and 0.02 by 0.125 mg/l at 10(6) cfu inoculum. The most potent antibacterial activity was shown by rifampicin, followed by ofloxacin, ciprofloxacin, enoxacin, norfloxacin, erythromycin and pipemidic acid in that order. The therapeutic efficacy of ciprofloxacin in experimental guinea pig pneumonia due to L. pneumophila was fairly good with a survival rate of 80%. From other data of ours, its effectiveness in experimental pneumonia was equal to or greater than that of erythromycin. Further studies would be appropriate to investigate the possibility of using ciprofloxacin for the treatment of human L. pneumophila infection.
AuthorsA Saito, H Koga, H Shigeno, K Watanabe, K Mori, S Kohno, Y Shigeno, Y Suzuyama, K Yamaguchi, M Hirota
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 18 Issue 2 Pg. 251-60 (Aug 1986) ISSN: 0305-7453 [Print] England
PMID3759736 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Ciprofloxacin
Topics
  • Animals
  • Anti-Bacterial Agents (pharmacology)
  • Ciprofloxacin (metabolism, therapeutic use)
  • Guinea Pigs
  • Legionella (drug effects)
  • Legionnaires' Disease (drug therapy)
  • Male

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