Abstract |
The pathogen spectrum of wound infections in colon surgery is composed almost exclusively of facultatively aerobic and obligatorily anaerobic intestinal flora. A study was performed in which a one-shot prophylaxis was carried out by applying metronidazole, 500 mg i.v., or latamoxef ( lamoxactam) 2 g i.v., on induction of anesthesia. The metronidazole group evidenced a 26.3% incidence of infections due exclusively to aerobic pathogens. In the latamoxef ( lamoxactam) group, it was possible to achieve a reduction of the postoperative rate of wound infections to 11.1%. The study was prematurely terminated because of the high rate of wound infections in the metronidazole group and the exclusive selecting of aerobic pathogens.
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Authors | G Raetzel, B M Harnoss, G Görtz, R Häring, A Rodloff |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 36
Issue 6
Pg. 976-80
(Jun 1986)
ISSN: 0004-4172 [Print] Germany |
Vernacular Title | Systemische Antibiotikaprophylaxe mit Metronidazol in der elektiven Kolon- und Rektumchirurgie. Ergebnisse einer klinisch-kontrollierten Studie und kritische Literaturübersicht. |
PMID | 3741534
(Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Colon
(surgery)
- Humans
- Metronidazole
(therapeutic use)
- Premedication
- Rectum
(surgery)
- Surgical Wound Infection
(microbiology, prevention & control)
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