Lipid peroxidation dependent aldrin epoxidation in liver microsomes, hepatocytes and granulation tissue cells.

Abstract

Lipid peroxidation activity was determined in liver microsomes, hepatocytes and cultured granuloma cells by measuring ethane and pentane production with an improved capillary gas chromatographic method. Lipid peroxidation initiated by ferrous ions and NADPH produced significantly more hydrocarbons at 4% O2 than under atmospheric (21% O2), hyperoxic or hypoxic conditions. In liver microsomes ferrous ions and ascorbic acid stimulated the non-enzymatic lipid peroxidation and concomitantly the epoxidation of aldrin. The results demonstrate that epoxidation of aldrin can be triggered by the iron initiated lipid peroxidation.

• Authors: B Lang, P Maier
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 138 Issue 1 Pg. 24-32 (Jul 16 1986) ISSN: 0006-291X [Print] United States
• PMID: 3741413 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Epoxy Compounds
• Ferrous Compounds
• Lipid Peroxides
• Pentanes
• pentane
• NADP
• Dieldrin
• Ethane
• Aldrin
• Ascorbic Acid

Topics

• Aldrin (metabolism)
• Animals
• Ascorbic Acid (pharmacology)
• Chromatography, Gas
• Dieldrin (analysis)
• Epoxy Compounds (metabolism)
• Ethane (analysis)
• Ferrous Compounds (pharmacology)
• Granuloma (metabolism)
• Lipid Peroxides (metabolism)
• Liver (metabolism)
• Male
• Microsomes, Liver (metabolism)
• NADP (pharmacology)
• Pentanes (analysis)
• Rats
• Rats, Inbred Strains