Clinical field trial of praziquantel in opisthorchiasis in Nong Rangya Village, Khon Kaen Province, Thailand.

Abstract

A clinical field trial of praziquantel was carried out in Nong Ranya Village, Amphoe Ban Phai, Khon Kaen Province, with a population of 309 individuals, and 94% prevalence rate of opisthorchiasis. A mass treatment was carried out using a single dose of praziquantel at 40 mg per kg body weight. Acceptance for treatment was 91%. Follow-up stool examinations performed on days 14 and 60 gave prevalence rates of 20.5% and 22.2% respectively. Side effects including dizziness, headache, abdominal discomfort, nausea, vomiting, diarrhoea, lassitude, arthralgia, sleepiness, cramps and hot sensation were the complaints from 80% of adults and 40% of children. All of these were mild and transient except in one adult female who had severe diarrhoea and required intravenous fluid infusion.

• Authors: C Viravan, D Bunnag, T Harinasuta, S Upatham, S Kurathong, V Viyanant
• Journal: The Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 17 Issue 1 Pg. 63-6 (Mar 1986) ISSN: 0125-1562 [Print] Thailand
• PMID: 3738609 (Publication Type: Journal Article)

Chemical References

• Praziquantel

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Feces (parasitology)
• Female
• Humans
• Male
• Middle Aged
• Opisthorchiasis (drug therapy, epidemiology)
• Praziquantel (adverse effects, therapeutic use)
• Thailand