The effect of tetrahydrofolate on tetrahydrobiopterin metabolism.

Abstract	5-Methyltetrahydrofolate and vitamin B12 appear to be required for the biosynthesis of tetrahydrobiopterin. A deficiency of either could be sufficient to bring about neurological change which can be corrected by reversing the deficiency. Patients with senile dementia could possibly be benefited by the administration of 5-methyltetrahydrofolate.
Authors	C G Hamon, J A Blair, P A Barford
Journal	Journal of mental deficiency research (J Ment Defic Res) Vol. 30 ( Pt 2) Pg. 179-83 (Jun 1986) ISSN: 0022-264X [Print] England
PMID	3735413 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Pteridines Tetrahydrofolates Biopterin sapropterin Vitamin B 12 5-methyltetrahydrofolate
Topics	Adult Aged Alzheimer Disease (drug therapy, metabolism) Animals Biopterin (analogs & derivatives, biosynthesis) Child, Preschool Humans In Vitro Techniques Infant Male Middle Aged Pteridines (biosynthesis) Rats Rats, Inbred Strains Temporal Lobe (metabolism) Tetrahydrofolates (pharmacology) Vitamin B 12 (pharmacology)

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