During the National Cooperative
Gallstone Study,
chenodiol (
chenodeoxycholate), 750 or 375 mg/day, resulted in complete
gallstone dissolution in only 13.5% and 5.2% of patients, respectively. The purpose of this study was to analyze the composition and morphology of
gallstones from patients who underwent
cholecystectomy during the National Cooperative
Gallstone Study to determine if
calcium salts on the
gallstone surface could have been responsible for failure of dissolution. Total
gallstone calcium content was not different between the treated and placebo groups; however, surface
calcium levels were different, being greater than 1.0% in 47.6% of stones from
chenodiol-treated patients (n = 63) but in only 16.7% of those from placebo-treated patients (n = 18), p less than 0.02. Pigmented outer rims were found in 52.4% of the stones from the
chenodiol-treated group compared with only 16.7% of stones from the placebo group, p less than 0.01. The rim
calcium content of 36 stones with pigmented outer rims was 3.7% +/- 1.0%, whereas that of 45 stones with nonpigmented outer rims was only 1.0% +/- 0.3%, p less than 0.01. We conclude that the presence of rings of increased concentrations of
calcium salts on the
gallstone surface may impair dissolution by
chenodiol.