[Use of malate and NAD for the correction of the blood supply and oxygen balance of the acutely ischemic myocardium].

Abstract

The experiments on cats under the conditions of acute myocardial ischemia showed that malate (20 and 100 mg/kg) and NAD (0.2 and 2 mg/kg) are able of increasing the coronary blood flow against the background of insignificantly increased oxygen consumption by the heart. The combination of these drugs (malate 100 mg/kg + NAD 0.2 mg/kg) produces an increase in the coronary blood flow and a dramatic raise in cardiac oxygen consumption.

• Authors: V I Kostin
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1986 May-Jun Vol. 49 Issue 3 Pg. 44-6 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Primenenie malata i NAD dlia korrektsii krovoobrashcheniia i kislorodnogo balansa ostroishemizirovannogo miokarda.
• PMID: 3720933 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Malates
• NAD

Topics

• Acute Disease
• Animals
• Cats
• Coronary Circulation (drug effects)
• Coronary Disease (drug therapy, physiopathology)
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Female
• Malates (therapeutic use)
• Male
• Myocardium (metabolism)
• NAD (therapeutic use)
• Oxygen Consumption (drug effects)