Nicardipine: protection against brain hypoxia.

Abstract

Nicardipine, a new vasodilator and calcium antagonist, was tested for antihypoxic activity on the central nervous system. Two methods were used: hypobaric hypoxia and alteration of the electrocorticogram by asphyxic anoxia. Both survival time and the impaired electrical signal were improved by nicardipine. These results suggest brain protection by increased cerebral blood supply.

• Authors: J L Montero, M Grau, J Balasch
• Journal: Drugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 12 Issue 5 Pg. 377-80 ( 1986) ISSN: 0378-6501 [Print] Switzerland
• PMID: 3720521 (Publication Type: Journal Article)

Chemical References

• Vasodilator Agents
• Nicardipine
• Nifedipine

Topics

• Animals
• Cerebral Cortex (drug effects, physiology)
• Electroencephalography
• Hypoxia, Brain (prevention & control)
• Male
• Mice
• Nicardipine
• Nifedipine (analogs & derivatives, pharmacology)
• Rats
• Rats, Inbred Strains
• Time Factors
• Vasodilator Agents