[Cyclosporin treatment in uveitis].

Abstract

With Cyclosporin, a recently developed immunosuppressant drug, the authors treated eight patients with noninfectious chronic uveitis: intermediate uveitis (4), Behcet's disease (2), chorioiditis (1), and anterior uveitis (1). Therapy had to be discontinued in six patients who responded poorly or manifested severe side effects. In four cases the Cyclosporin concentration in the aqueous humor was determined. In spite of a concentration of about 900 ng/ml there was a deterioration in two cases with intermediate uveitis and Behcet's disease. Only one of the eight patients with intermediate uveitis responded well without any recurrence.

• Authors: C D Quentin, M Vogel
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 188 Issue 3 Pg. 248-50 (Mar 1986) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: Ciclosporin-Behandlung bei Uveitis.
• PMID: 3713099 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cyclosporins

Topics

• Adolescent
• Adult
• Autoimmune Diseases (drug therapy)
• Child
• Cyclosporins (adverse effects, blood, therapeutic use)
• Female
• Humans
• Male
• Metabolic Clearance Rate
• Middle Aged
• Recurrence
• Uveitis (drug therapy)