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Superoxide dismutase isoenzymes in cerebrospinal fluid and plasma from patients with neuronal ceroid-lipofuscinoses.

Abstract
The neuronal ceroid-lipofuscinoses is a group of diseases characterized by a widespread accumulation in the body of pigments believed to be end-products of lipid-peroxidation damaged organelles. It was recently shown that cerebrospinal fluid from patients with infantile and juvenile neuronal ceroid-lipofuscinosis were less protective against superoxide radical-induced hydroxyl radical formation compared with controls. The content of superoxide dismutase isoenzymes in cerebrospinal fluid and in plasma from patients with different forms of neuronal ceroid-lipofuscinosis was analysed. No significant difference from controls could be demonstrated in samples from patients with juvenile neuronal ceroid-lipofuscinosis. The few samples from patients with infantile and late infantile neuronal ceroid-lipofuscinosis analysed all fell within the range defined by the controls.
AuthorsS L Marklund, H Heiskala, T Westermarck, P Santavuori
JournalClinical science (London, England : 1979) (Clin Sci (Lond)) Vol. 71 Issue 1 Pg. 57-60 (Jul 1986) ISSN: 0143-5221 [Print] England
PMID3709075 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Isoenzymes
  • Superoxide Dismutase
Topics
  • Adult
  • Age Factors
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Isoenzymes (blood, cerebrospinal fluid)
  • Male
  • Neuronal Ceroid-Lipofuscinoses (enzymology)
  • Superoxide Dismutase (blood, cerebrospinal fluid)

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