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On-line clarification for the measurement of serum glucose in hyperlipidemic specimens.

Abstract
The optical aberrations due to the presence of the turbidity caused by hyperlipidemia has been eliminated in two serum glucose procedures. This has been accomplished by incorporating lipase and alpha-cyclodextrin into the two glucose reagents. The hydrolytic action of the lipase generates water soluble glycerol and insoluble fatty acids. By including the chemical scavenger alpha-cyclodextrin into the reagent the fatty acids are solubilized and thus the production of a second turbidity is avoided. Because the clearing reagents are incorporated into the glucose reagents, this is an on-line process and no additional labor is required to clear the sample-reagent mixture. Furthermore, no additional time is required as the clearing occurs in the same period of time that it takes for the indicator reactions to reach equilibrium.
AuthorsJ D Artiss, D R Strandbergh, A Sharma, B Zak
JournalClinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 156 Issue 2 Pg. 151-6 (Apr 30 1986) ISSN: 0009-8981 [Print] Netherlands
PMID3708861 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Cyclodextrins
  • Fatty Acids, Nonesterified
  • Indicators and Reagents
  • Triglycerides
  • alpha-Cyclodextrins
  • Glucose Oxidase
  • Hexokinase
  • Lipase
  • alpha-cyclodextrin
Topics
  • Blood Glucose (analysis)
  • Cyclodextrins
  • Fatty Acids, Nonesterified (blood)
  • Glucose Oxidase
  • Hexokinase
  • Humans
  • Hyperlipidemias (blood)
  • Indicators and Reagents
  • Lipase
  • Spectrophotometry
  • Triglycerides (blood)
  • alpha-Cyclodextrins

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