The effect of vasopressin upon the cochlear potentials in the guinea pig.

Abstract

The change in the EP, CM, SP and AP during perilymphatic perfusion of vasopressin (antidiuretic hormone) was examined in the guinea pig. The EP was recorded with a microelectrode through the spiral ligament of the second turn. The CM, SP and AP were measured with the differential electrodes in the basal turn. The perfusion of vasopressin at concentration of more than 10(-5)M produced a reversible decrease in the EP. The extent of the EP decline was dependent upon the concentration of vasopressin. Abolition of the effect of vasopressin upon the EP by the resumption of respiration after transient asphyxia was observed. During the perfusion of vasopressin, the CM and AP decreased, while the negative component of the SP increased. The mechanism causing the effect of vasopressin upon the cochlear potentials is discussed.

• Authors: N Mori, K Ohta, T Matsunaga
• Journal: Acta oto-laryngologica (Acta Otolaryngol) 1986 Mar-Apr Vol. 101 Issue 3-4 Pg. 217-23 ISSN: 0001-6489 [Print] England
• PMID: 3705950 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vasopressins

Topics

• Action Potentials (drug effects)
• Animals
• Cochlea (drug effects)
• Cochlear Microphonic Potentials (drug effects)
• Evoked Potentials, Auditory (drug effects)
• Guinea Pigs
• Microelectrodes
• Vasopressins (administration & dosage, pharmacology)