Adaptation to cold antagonizes neurotensin-induced hypothermia in mice.

Abstract

Intracerebrally-administered neurotensin produces a marked hypothermia in a variety of mammals. In this study, prior adaptation to a cold environment was found to significantly antagonize the hypothermia produced by intracisternally-administered neurotensin in mice. This antagonism required both previous exposure to cold ambient temperatures and cold exposure immediately prior to, or simultaneously with, neurotensin administration. The antagonism of neurotensin-induced hypothermia by prior cold-adaptation was blocked by indomethacin, but not by acetylsalicylic acid, suggesting that brain prostaglandin synthesis may be essential for this newly-discovered phenomenon.

• Authors: W D Merritt, G Bissette, D Luttinger, A J Prange Jr, C B Nemeroff
• Journal: Brain research (Brain Res) Vol. 369 Issue 1-2 Pg. 136-42 (Mar 26 1986) ISSN: 0006-8993 [Print] Netherlands
• PMID: 3697737 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Prostaglandins
• Neurotensin

Topics

• Adaptation, Physiological
• Animals
• Body Temperature (drug effects)
• Brain (drug effects)
• Cold Temperature
• Hypothalamo-Hypophyseal System (physiology)
• Injections
• Male
• Mice
• Neurotensin (pharmacology)
• Prostaglandins (physiology)
• Subarachnoid Space
• Thyroid Gland (physiology)