Significance of renal hyaline arteriolosclerosis and tubulo-interstitial change in IgA glomerulonephropathy and focal glomerular sclerosis.

Abstract

The relationship between glomerular sclerosis and hyaline arteriolosclerosis (HA) or tubulo-interstitial (T-I) change was investigated in 66 patients with IgA glomerulonephropathy (IgA-GN) and in 12 patients with idiopathic focal segmental glomerulosclerosis (FGS). More than a 10% incidence of global sclerosis was noted in 15 patients with IgA-GN and in 9 patients with FGS. There was no significant discrepancy of age between patients with IgA-GN and those with FGS (IgA-GN: 37.5 +/- 12.5; FGS: 35.7 +/- 10.3). In patients with IgA-GN, 7 out of 15 were HA-positive (46.7%), whereas in patients with FGS, 7 out of 9 were HA-positive (77.8%). However, a close correlation was observed between glomerular sclerosis and T-I change only in patients with IgA-GN (r = 0.82; p less than 0.001). The results suggested that in the case of IgA-GN, T-I change was related to the prognosis of glomerular sclerosis. In addition, it is assumed that a possible correlation exists between FGS and HA.

• Authors: O Hotta, N Yoshizawa, S Oshima, A Takeuchi, O Kawamura, S Kondo, T Kubota, H Niwa
• Journal: Nephron (Nephron) Vol. 47 Issue 4 Pg. 262-5 ( 1987) ISSN: 1660-8151 [Print] Switzerland
• PMID: 3696327 (Publication Type: Journal Article)

Chemical References

• Creatinine

Topics

• Adolescent
• Adult
• Aged
• Arteriosclerosis (complications, pathology)
• Creatinine (blood)
• Female
• Glomerulonephritis (complications)
• Glomerulonephritis, IGA (complications, pathology)
• Glomerulosclerosis, Focal Segmental (complications, pathology)
• Humans
• Male
• Middle Aged
• Nephritis, Interstitial (complications, pathology)