Surgery in combined pulmonary and neural cryptococcosis.

Abstract

A 39-year-old previously healthy patient with combined pulmonary and neural cryptococcosis was successfully managed by pulmonary resection and antifungal chemotherapy. The pulmonary mass was removed under cover of miconazole and 5-fluorocytosine even though the patient had concomitant active meningitis. He recovered dramatically after the surgical procedure and remained well 2 years later. We suggest that, as in our patient, early removal of a pulmonary cryptococcal mass under antifungal cover may in other similar patients obviate the need for protracted antifungal therapy and lead to an excellent response of the neural cryptococcosis.

• Authors: M A Sa'adah, R A Shakir, S I Jadaa, V Bezjak, G F Araj
• Journal: The Journal of infection (J Infect) Vol. 15 Issue 3 Pg. 263-8 (Nov 1987) ISSN: 0163-4453 [Print] England
• PMID: 3693927 (Publication Type: Case Reports, Journal Article)

Chemical References

• Miconazole
• Flucytosine

Topics

• Adult
• Combined Modality Therapy
• Cryptococcosis (drug therapy, surgery)
• Flucytosine (therapeutic use)
• Humans
• Lung Diseases, Fungal (complications, surgery)
• Male
• Meningitis (complications, drug therapy)
• Miconazole (therapeutic use)