R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle.

Abstract

The effect of the new compound R 56865 on ouabain-induced intoxication (8 X 10(-7) mol/l) was studied in guinea-pig papillary muscle. The positive inotropism induced by ouabain was not impaired by R 56865. Mechanical signs of intoxication, e.g. extrasystoles and contracture, as well as the development of spike-like action potentials could be prevented by pretreatment with R 56865 (3 X 10(-10)-10(-6) mol/l). We speculate that this new compound prevents ouabain-induced Ca overload of cardiac muscle.

• Authors: B Vollmer, C Meuter, P A Janssen
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 142 Issue 1 Pg. 137-40 (Oct 06 1987) ISSN: 0014-2999 [Print] Netherlands
• PMID: 3691632 (Publication Type: Journal Article)

Chemical References

• Benzothiazoles
• Piperidines
• Thiazoles
• Ouabain
• R 56865
• Calcium

Topics

• Animals
• Arrhythmias, Cardiac (chemically induced, physiopathology)
• Benzothiazoles
• Calcium (physiology)
• Electrophysiology
• Guinea Pigs
• Heart (drug effects, physiology)
• In Vitro Techniques
• Ouabain (antagonists & inhibitors, toxicity)
• Papillary Muscles (drug effects)
• Piperidines (pharmacology)
• Thiazoles (pharmacology)