Abstract |
Since January 1980, 110 children having 113 attacks of Kawasaki syndrome were studied. Age at onset was 7 weeks to 12 years (mean 3 6/12 years, median 2 9/12 years); 77% were younger than 5 years of age; the male to female ratio was 1.8; racial distribution was 52% white, 19% black, 14% Hispanic, and 16% Asian. Protocol of management consisted of high-dose aspirin (100 mg/kg/d) until afebrile, and then 81 mg every day until free of coronary aneurysm. Two-dimensional echocardiograms were done weekly during the acute stage, at 2 and 6 months after onset, and yearly if a coronary abnormality was detected. At 1 month, 51 coronary arterial abnormalities were present in 25 patients. Risk factors for a coronary abnormality were duration of fever greater than or equal to 2 weeks, level of platelet count, marked elevation of ESR, and age younger than 5 years. No statistically significant difference in incidence of aneurysms was detected between patients on high-dose aspirin and those on medium-or low-dose aspirin.
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Authors | F Ichida, N S Fatica, M A Engle, J E O'Loughlin, A A Klein, M S Snyder, K H Ehlers, A R Levin |
Journal | Pediatrics
(Pediatrics)
Vol. 80
Issue 6
Pg. 828-35
(Dec 1987)
ISSN: 0031-4005 [Print] United States |
PMID | 3684392
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aspirin
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Coronary Aneurysm
(etiology, prevention & control)
- Female
- Humans
- Infant
- Male
- Mucocutaneous Lymph Node Syndrome
(complications, drug therapy)
- New York
- Risk Factors
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