Trial of ganglioside therapy for diabetic neuropathy.

Abstract

The efficacy of daily intramuscular injection of mixed gangliosides (Cronassial) for highly symptomatic diabetic neuropathy was investigated in a randomized double-blind trial. There were 37 patients treated with 40 mg of gangliosides or placebo for 12 weeks and studied with physical examination, symptom scales, and electrophysiologic parameters. There was no demonstrated benefit of therapy. Given the spontaneous variation in the measurements employed, larger numbers of patients would have been needed to identify a significant change of 10% owing to therapy.

• Authors: M Hallett, T Flood, N Slater, J Dambrosia
• Journal: Muscle & nerve (Muscle Nerve) 1987 Nov-Dec Vol. 10 Issue 9 Pg. 822-5 ISSN: 0148-639X [Print] United States
• PMID: 3683453 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Gangliosides

Topics

• Adult
• Aged
• Diabetic Neuropathies (drug therapy)
• Drug Evaluation
• Female
• Gangliosides (therapeutic use)
• Humans
• Male
• Middle Aged
• Neural Conduction (drug effects)
• Random Allocation