Tocopheryl polyethylene glycol 1000 succinate therapy for vitamin E deficiency during chronic childhood cholestasis: neurologic outcome.

Abstract

Treatment of the vitamin E deficiency neurologic syndrome in children with chronic cholestasis is hampered by the very poor intestinal absorption of available forms of vitamin E, thus requiring prolonged treatment with intramuscular injections of vitamin E in many patients. D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) is a water-soluble investigational form of vitamin E that is well absorbed during cholestasis. We studied the effect of TPGS therapy on the neurologic function in 12 children with vitamin E deficiency (aged 9 months to 6 years) with prolonged forms of neonatal cholestasis. Each child had failed to respond to up to 100 to 200 IU/kg/d of standard oral preparations of vitamin E. Treatment with 15 to 25 IU/kg/d TPGS for a mean of 19.3 months normalized the biochemical indices of vitamin E status and was well tolerated by all patients. Neurologic function, assessed by serial neurologic examinations, remained normal during therapy in the two children with no neurologic symptoms younger than age 3 years at onset of therapy. Neurologic function, which had deteriorated before this study, improved in six of seven patients with symptoms who were younger than 3 years and in all three with symptoms older than 3 years. TPGS appears to be a safe and effective form of orally administered vitamin E for use in children with chronic cholestasis who are unresponsive to available oral preparations of vitamin E.

• Authors: R J Sokol, N A Butler-Simon, D Bettis, D J Smith, A Silverman
• Journal: The Journal of pediatrics (J Pediatr) Vol. 111 Issue 6 Pt 1 Pg. 830-6 (Dec 1987) ISSN: 0022-3476 [Print] United States
• PMID: 3681546 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Vitamin E
• Polyethylene Glycols
• tocophersolan

Topics

• Child, Preschool
• Cholestasis (complications)
• Chronic Disease
• Female
• Humans
• Infant
• Male
• Nervous System Diseases (drug therapy, etiology)
• Polyethylene Glycols
• Vitamin E (analogs & derivatives, therapeutic use)
• Vitamin E Deficiency (drug therapy, etiology)